A collimated, ionized bipolar structure and a high density torus in the young planetary nebula IRAS 17347-3139

We present observations of continuum (lambda = 0.7, 1.3, 3.6 and 18 cm) and OH maser (lambda = 18 cm) emission toward the young planetary nebula IRAS 17347-3139, which is one of the three planetary nebulae that are known to harbor water maser emission. From the continuum observations we show that the ionized shell of IRAS 17347-3139 consists of two main structures: one extended (size ~1". 5) with bipolar morphology along PA=-30 degrees, elongated in the same direction as the lobes observed in the near-infrared images, and a central compact structure (size ~0". 25) elongated in the direction perpendicular to the bipolar axis, coinciding with the equatorial dark lane observed in the near-infrared images. Our image at 1.3 cm suggests the presence of dense walls in the ionized bipolar lobes. We estimate for the central compact structure a value of the electron density at least ~5 times higher than in the lobes. A high resolution image of this structure at 0.7 cm shows two peaks separated by about 0". 13 (corresponding to 100-780 AU, using a distance range of 0.8-6 kpc). This emission is interpreted as originating in an ionized equatorial torus-like structure, from whose edges the water maser emission might be arising. We have detected weak OH 1612 MHz maser emission at VLSR ~ -70 km/s associated with IRAS 17347-3139. We derive a 3 sigma upper limit of < 35% for the percentage of circularly polarized emission. Within our primary beam, we detected additional OH 1612 MHz maser emission in the LSR velocity ranges -5 to -24 and -90 to -123 km/s, associated with the sources 2MASS J17380406-3138387 and OH 356.65-0.15, respectively.Comment: 26 pages, 8 figures. Accepted for publication in Ap

Water maser detections in southern candidates to post-AGB stars and Planetary Nebulae

We intended to study the incidence and characteristics of water masers in the envelopes of stars in the post-AGB and PN evolutionary stages. We have used the 64-m antenna in Parkes (Australia) to search for water maser emission at 22 GHz, towards a sample of 74 sources with IRAS colours characteristic of post-AGB stars and PNe, at declination $< -32 \deg$. In our sample, 39% of the sources are PNe or PNe candidates, and 50% are post-AGB stars or post-AGB candidates. We have detected four new water masers, all of them in optically obscured sources: three in PNe candidates (IRAS 12405-6219, IRAS 15103-5754, and IRAS 16333-4807); and one in a post-AGB candidate (IRAS 13500-6106). The PN candidate IRAS 15103-5754 has water fountain characteristics, and it could be the first PN of this class found. We confirm the tendency suggested in Paper I that the presence of water masers in the post-AGB phase is favoured in obscured sources with massive envelopes. We propose an evolutionary scenario for water masers in the post-AGB and PNe stages, in which ``water fountain'' masers could develop during post-AGB and early PN stages. Later PNe would show lower velocity maser emission, both along jets and close to the central objects, with only the central masers remaining in more evolved PNe.Comment: 11 pages, 5 figures. Accepted by Astronomy and Astrophysic

Evaluation in a Cytokine Storm Model in Vivo of the Safety and Efficacy of Intravenous Administration of PRS CK STORM (Standardized Conditioned Medium Obtained by Coculture of Monocytes and Mesenchymal Stromal Cells)

Our research group has been developing a series of biological drugs produced by cocul-ture techniques with M2-polarized macrophages with different primary tissue cells and/or mesen-chymal stromal cells (MSC), generally from fat, to produce anti-inflammatory and anti-fibrotic ef-fects, avoiding the overexpression of pro-inflammatory cytokines by the innate immune system at a given time. One of these products is the drug PRS CK STORM, a medium conditioned by allogenic M2-polarized macrophages, from coculture, with those macrophages M2 with MSC from fat, whose composition, in vitro safety, and efficacy we studied. In the present work, we publish the results obtained in terms of safety (pharmacodynamics and pharmacokinetics) and efficacy of the intravenous application of this biological drug in a murine model of cytokine storm associated with severe infectious processes, including those associated with COVID-19. The results demonstrate the safety and high efficacy of PRS CK STORM as an intravenous drug to prevent and treat the cytokine storm associated with infectious processes, including COVID-19

Cytokine profile and anti-inflammatory activity of a standardized conditioned medium obtained by coculture of monocytes and mesenchymal stromal cells (PRS CK STORM)

Intercellular communication between monocytes/macrophages and cells involved in tissue regeneration, such as mesenchymal stromal cells (MSCs) and primary tissue cells, is essential for tissue regeneration and recovery of homeostasis. Typically, in the final phase of the inflammation-resolving process, this intercellular communication drives an anti-inflammatory immunomodulatory response. To obtain a safe and effective treatment to counteract the cytokine storm associated with a disproportionate immune response to severe infections, including that associated with COVID-19, by means of naturally balanced immunomodulation, our group has standardized the production under GMP-like conditions of a secretome by coculture of macrophages and MSCs. To characterize this proteome, we determined the expression of molecules related to cellular immune response and tissue regeneration, as well as its possible toxicity and anti-inflammatory potency. The results show a specific molecular pattern of interaction between the two cell types studied, with an anti-inflammatory and regenerative profile. In addition, the secretome is not toxic by itself on human PBMC or on THP-1 monocytes and prevents lipopolysaccharide (LPS)-induced growth effects on those cell types. Finally, PRS CK STORM prevents LPS-induced TNF-A and IL-1B secretion from PBMC and from THP-1 cells at the same level as hydrocortisone, demonstrating its anti-inflammatory potency. © 2022 by the authors. Licensee MDPI, Basel, Switzerland

Search for an annual modulation of dark-matter signals with a germanium spectrometer at the Sierra Grande Laboratory

Data collected during three years with a germanium spectrometer at the Sierra Grande underground laboratory have been analyzed for distinctive features of annual modulation of the signal induced by WIMP dark matter candidates. The main motivation for this analysis was the recent suggestion by the DAMA/NaI Collaboration that a yearly modulation signal could not be rejected at the 90% confidence level when analyzing data obtained with a high-mass low-background scintillator detector. We performed two different analyses of the data: First, the statistical distribution of modulation-significance variables (expected from an experiment running under the conditions of Sierra Grande) was compared with the same variables obtained from the data. Second, the data were analyzed in energy bins as an independent check of the first result and to allow for the possibility of a crossover in the expected signal. In both cases no statistically significant deviation from the null result was found, which could support the hypothesis that the data contain a modulated component. A plot is also presented to enable the comparison of these results to those of the DAMA collaboration.Comment: New version accepted by Astroparticle Physics. Changes suggested by the referee about the theoretical prediction of rates are included. Conclusions remain unaffected. 14 pages, LaTeX, 7 figures. Uses epsfig macr

IAA : Información y actualidad astronómica (30)

Sumario : Habitabilidad en el Universo.-- El imán de la Vía Láctea.-- El estudio del Universo frío.-- DECONSTRUCCIÓN Y otros ENSAYOS. Johannes Kepler.-- EL “MOBY DICK” DE... Matilde Fernández (IAA-CSIC).-- HISTORIAS DE ASTRONOMÍA. La noche de Noli.-- ACTUALIDAD.-- ENTRE BASTIDORES.-- CIENCIA: PILARES E INCERTIDUMBRES : Núcleos activos de galaxias.-- ACTIVIDADES IAA.N

Kinematics of the H2O masers at the centre of the PN K3-35

We have studied the kinematics traced by the water masers located at the centre of the planetary nebula (PN) K3-35, using data from previous Very Large Array (VLA) observations. An analysis of the spatial distribution and line-of-sight velocities of the maser spots allows us to identify typical patterns of a rotating and expanding ring in the position-velocity diagrams, according to our kinematical model. We find that the distribution of the masers is compatible with tracing a circular ring with a ~0.021 arcsec (~100 AU) radius, observed with an inclination angle with respect to the line of sight of 55 degrees. We derive expansion and rotation velocities of 1.4 and 3.1 km/s, respectively. The orientation of the ring projected on the plane of the sky, at PA 158 degrees, is almost orthogonal to the direction of the innermost region of the jet observed in K3-35, suggesting the presence of a disc or torus that may be related to the collimation of the outflow.Comment: 7 pages, 4 figures, 2 tables. Accepted by MNRA

The magnetic field toward the young planetary nebula K~3-35

K 3-35 is a planetary nebula (PN) where H2O maser emission has been detected, suggesting that it departed from the proto-PNe phase only some decades ago. Interferometric VLA observations of the OH 18 cm transitions in K~3-35 are presented.OH maser emission is detected in all four ground state lines (1612, 1665, 1667, and 1720 MHz). All the masers appear blueshifted with respect to the systemic velocity of the nebula and they have different spatial and kinematic distributions.The OH 1665 and 1720 MHz masers appear spatially coincident with the core of the nebula, while the OH 1612 and 1667 MHz ones exhibit a more extended distribution. We suggest that the 1665 and 1720 masers arise from a region close to the central star, possibly in a torus, while the 1612 and 1667 lines originate mainly from the extended northern lobe of the outflow. It is worth noting that the location and velocity of the OH 1720 MHz maser emission are very similar to those of the H2O masers (coinciding within 0.1" and ~2 km/s, respectively). We suggest that the pumping mechanism in the H2O masers could be produced by the same shock that is exciting the OH 1720 MHz transition. A high degree of circular polarization (>50%) was found to be present in some features of the 1612, 1665, and 1720 MHz emission.For the 1665 MHz transition at ~ +18 km/s the emission with left and right circular polarizations (LCP and RCP) coincide spatially within a region of ~0.03" in diameter.Assuming that these RCP and LCP 1665 features come from a Zeeman pair, we estimate a magnetic field of ~0.9 mG within 150 AU from the 1.3 cm continuum peak. This value is in agreement with a solar-type magnetic field associated with evolved stars.Comment: 6 pages, 2 tables, 4 figures, ApJ accepte

Pfeiffer syndrome. A case report

[ES]El síndrome de Pfeiffer (SP) es una enfermedad genética rara, descrita por Peiffer en 1964, que cursa con craneosinostosis, hipoplasia medio facial, sindactilia y pulgares gruesos con un amplio rango de severidad. Presentamos un caso, con revisión de la literatura. La obstrucción de la vía aérea superior en relación con la hipoplasia medio facial es una complicación frecuente en los casos graves, que debe valorarse y tratarse de manera precoz. [EN] Pfeiffer syndrome (PS) is a rare genetical disorder, originally described by Pfeiffer in 1964, and is characterized by craniosynostosis, regressed midface, syndactyly of hands and feet, and broad thumbs and big toes, with a wide range of variable severity. We report a case with a review of literature. Obstruction of the upper airway in relation to the midface hypoplasia is a frequent complication in severe cases to be assessed and treated early